Expanding the scope of sustainable peptide synthesis through post-linear synthesis reactions

Organic & Biomolecular Chemistry 2026 Open access

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Authors: Michael A. Malone, Matilde De Francisco Craparotta, Kirsty I. M. Arnott, Andrew G. Jamieson, Nicola Wade
DOI: 10.1039/d5ob01890k
Cited by: 4
References: 38

Abstract

disulfide bond and 1,4-disubstituted triazole formation proceeded effectively in NBP, as did N-terminal acetylation under mild conditions. These findings establish NBP as a practical and greener alternative to DMF for diverse post-linear synthesis modifications, supporting the development of sustainable SPPS protocols.

Fields of Study & Subjects

Chemical Synthesis and Analysis Microbial Natural Products and Biosynthesis Biochemical and Structural Characterization

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
7
Pages
1496–1502
Publication date
1 January 2026
Language
EN