The enantioselective total synthesis of ROCK-inhibitor ( S )-Netarsudil (Rhopressa) via asymmetric organocatalysis

Organic & Biomolecular Chemistry 2026

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Authors: Ruslan A. Kovalevsky, Alexander S. Kucherenko, Sergei Grigorievich Zlotin
DOI: 10.1039/d5ob01899d
Cited by: 0
References: 21

Abstract

)-configuration. The advantages of the proposed methodology over the currently known one are the higher overall yield of the target drug, use of a reusable organocatalyst, mild and green reaction conditions, and the elimination of labor-intensive and time-consuming stages for the isolation of auxiliary groups.

Fields of Study & Subjects

Synthetic Organic Chemistry Methods Axial and Atropisomeric Chirality Synthesis Plant-derived Lignans Synthesis and Bioactivity

Publication details

Journal / source
Organic & Biomolecular Chemistry
Volume
24
Issue
5
Pages
1137–1142
Publication date
1 January 2026
Language
EN