Unusual C-2 selectivity of Grignard additions to N -Boc-protected isatin 3-imines

Organic & Biomolecular Chemistry 2026 Open access

Read full text
Authors: Alexandra Mary Plakas, Kamogelo Rosinah Butsi, Sahil Lala, Robyn Lynne van Zyl, Manuel Fernandes, Songeziwe Ntsimango, Moira Leanne Bode, Amanda L. Rousseau
DOI: 10.1039/d5ob01909e
Cited by: 0
References: 39

Abstract

A series of N-tert -butoxycarbonyl-protected isatin 3-imines underwent an unexpected C-2 selective addition reaction with Grignard reagents, affording 3-imino-2-phenethylindolin-2-ols.

Fields of Study & Subjects

Asymmetric Synthesis and Catalysis Synthesis of Indole Derivatives Advanced Synthetic Organic Chemistry

Publication details

Journal / source
Organic & Biomolecular Chemistry
Volume
24
Issue
8
Pages
1672–1677
Publication date
1 January 2026
Language
EN