Chemo- and diastereoselective synthesis of spiro-iminoindoline-pyrazolines as potential antioxidant reagents

Organic & Biomolecular Chemistry 2026

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Authors: Yuan-Hang Tian, Qi-Chun Yang, Yu-Xuan Liu, Peng Qin, Jun-Long Li, Yi-Qi Wu, Rong Zeng, Dong-Ming Zhang, Xiang Zhang, Haijun Leng
DOI: 10.1039/d5ob01910a
Cited by: 1
References: 78

Abstract

The construction of spiro-iminoindoline-pyrazolines from readily available starting materials has garnered significant interest within the synthetic chemistry community. Herein, we report a chemo- and diastereoselective (2 + 3) and three-component formal (1 + 1 + 3) cascade cyclization strategy for their synthesis, demonstrating unprecedented CC chemoselectivity of nitrile imines toward α,β-unsaturated imines. This method delivers multifunctionalized products efficiently under mild conditions. Furthermore, preliminary antioxidant screening using the DPPH radical scavenging assay highlights their potential bioactivity.

Fields of Study & Subjects

Multicomponent Synthesis of Heterocycles Synthesis and biological activity Synthesis and Reactivity of Heterocycles

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
7
Pages
1488–1495
Publication date
1 January 2026
Language
EN