Ruthenium-catalyzed direct C2–H selenylation of (benz)imidazoles

Organic & Biomolecular Chemistry 2026

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Authors: Dandan Liu, Chu Zou, Shu-Ting Hu, Wen-Jing Xu, Wan Xu, Merziya Keram, Xin Xu, Zhou Xu, Yu‐Chao Yuan
DOI: 10.1039/d5ob01926e
Cited by: 0
References: 83

Abstract

A ruthenium-catalyzed method has been developed for the direct C2-H selenylation of (benz)imidazole, enabling efficient selenium incorporation at the C2 position to yield diverse selenylated derivatives. This system operates under mild conditions with a broad substrate scope, excellent functional group tolerance, and high regioselectivity. Notably, diaryl disulfides were also successfully employed under identical conditions.

Fields of Study & Subjects

Organoselenium and organotellurium chemistry Catalytic C–H Functionalization Methods Sulfur-Based Synthesis Techniques

Publication details

Journal / source
Organic & Biomolecular Chemistry
Volume
24
Issue
6
Pages
1247–1251
Publication date
1 January 2026
Language
EN