One-pot synthesis of α-(OCH 2 CF 3 )-substituted pyridines using TFE as both a solvent and a reagent
Abstract
)-substituted pyridine-3,5-dicarbonitriles from readily available starting materials such as benzaldehydes, malononitrile, and trifluoroethanol (TFE), using a base. In this process, TFE serves a dual role as both the solvent and the source of the trifluoroethoxy group. Delightfully, diverse substituted benzaldehydes were efficiently transformed into the corresponding trifluoroethoxy-substituted pyridines in 54-95% yields. The reaction proceeds under mild conditions, avoids the need for pre-functionalized substrates, and exhibits broad functional group tolerance, providing a practical method for synthesizing diverse trifluoroethoxy-substituted pyridines.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Synthesis of heterocyclic compounds
Multicomponent Synthesis of Heterocycles
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Volume
- 24
- Issue
- 6
- Pages
- 1268–1273
- Publication date
- 1 January 2026
- Language
- EN