B(C 6 F 5 ) 3 /I 2 co-mediated cascade [4 + 2]/[3 + 2] cyclization to access spiroimidazolines
Abstract
, this one-pot, metal-free method assembles two rings from three readily available starting materials, affording a diverse library of products in up to 88% yields. Key to its practicality are the high step- and atom-economy, avoidance of pre-constructed rings, and operational simplicity. Mechanistic studies support a sequential pathway, offering a practical and sustainable approach to access privileged spiro scaffolds with potential medicinal chemistry applications.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Organoboron and organosilicon chemistry
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 24
- Issue
- 9
- Pages
- 1920–1925
- Publication date
- 1 January 2026
- Language
- EN