Synthesis of diverse substituted pyrimidines through Cu catalyst-controlled Ts group elimination and reinsertion pathway from 2 H -azirines with TosMICs
Abstract
-azirines with TosMICs have been developed that provide two efficient and modular approaches to diverse substituted pyrimidines with non-electron-withdrawing substituents at position 4 or 6. The Ts group of TosMIC plays a dual role as the sulfonyl source and the leaving group in the methodologies. Cascade reaction pathways comprising [3 + 2] cycloaddition, ring expansion, Ts group elimination-aromatization, Ts group reinsertion, and oxidative aromatization are also disclosed.
Fields of Study & Subjects
Synthesis and Catalytic Reactions
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 24
- Issue
- 10
- Pages
- 2046–2060
- Publication date
- 1 January 2026
- Language
- EN