An integrative chemical and genomic similarity approach linking fungal secondary metabolites and biosynthetic gene clusters

Organic & Biomolecular Chemistry 2026 Open access

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Authors: Karin Steffen, Manuel Rangel‐Grimaldo, Thomas J. C. Sauters, David C. Rinker, Huzefa A. Raja, Tyler N. Graf, Adiyantara Gumilang, Olivia L. Riedling, Gustavo Goldman, Nicholas H. Oberlies, Antonis Rokas
DOI: 10.1039/d5ob01965f
Cited by: 1
References: 95

Abstract

. Our approach assigned 22 to known SM-BGC pairs and proposed specific links to BGCs and genetic pathways for the remaining 38 metabolites. These results suggest that coupling chemical structure similarity and genomic sequence similarity is a straightforward and high-throughput approach for linking fungal SMs to their BGCs.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Fungal Biology and Applications Plant biochemistry and biosynthesis

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
6
Pages
1323–1338
Publication date
1 January 2026
Language
EN