Synthesis of α-chloro-β-ketoesters via ytterbium( iii ) triflate-mediated decarboxylative Claisen-type condensation
Abstract
-mediated decarboxylative Claisen-type condensation is established to access α-chloro-β-ketoesters. Operating under mild conditions, this method delivers products in 78-95% yields while circumventing the functional-group incompatibility and side reactions associated with conventional electrophilic chlorination of β-ketoesters. The synthetic utility of this method is further demonstrated by the synthesis of chlorinated 2-pyrones and asperphenylpyrone analogues, highlighting its potential for constructing structurally diverse and bioactive molecules.
Fields of Study & Subjects
Organic Chemistry Synthesis Methods
Chemical Synthesis and Reactions
Asymmetric Synthesis and Catalysis
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Volume
- 24
- Issue
- 11
- Pages
- 2283–2289
- Publication date
- 1 January 2026
- Language
- EN