Regio- and diastereoselective 1,2-hydroalkylation of 1,3-enynes via dual photoredox/Ti catalysis

Organic & Biomolecular Chemistry 2026

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Authors: Xiaoxia He, Hongjiang Li, Tao Huang, Fengzhen Li, Junru Wang, Zulin Xiao, Xueping Zong, Xin Xiong, Fusheng Li
DOI: 10.1039/d5ob01985k
Cited by: 1
References: 38

Abstract

cobalt-catalyzed MHAT and Ti-catalyzed reductive polar crossover. However, the reaction failed to proceed with aromatic aldehydes and ketones, likely due to steric hindrance or low electrophilicity. This approach enables the highly efficient preparation of homopropargylic alcohols with excellent diastereoselectivity (up to 20 : 1) and advances radical-based strategies for synthesizing complex active molecules.

Fields of Study & Subjects

Catalytic Alkyne Reactions Radical Photochemical Reactions Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
9
Pages
1837–1843
Publication date
1 January 2026
Language
EN