The Ugi–Joullié three-component reaction (UJ-3CR) and related reactions: recent developments, mechanistic aspects and synthesis of natural products and bioactive compounds

Organic & Biomolecular Chemistry 2026

View at publisher
Authors: Natalia A. Lenarduzzi D'emilio, Paula K Paz Armero, Arturo R. Mendoza Salgado, Sebastián O. Simonetti, Andrea B. J. Bracca, Enrique L. Larghi, Teodoro S. Kaufman
DOI: 10.1039/d5ob02009c
Cited by: 2
References: 248

Abstract

The Ugi-Joullié three-component reaction evolved from the classic Ugi four-component reaction and enables the facile and efficient formation of polysubstituted nitrogen heterocycles from cyclic imines, isonitriles and carboxylic acids. Recent progress in the field aiming to expand its scope is reviewed, with an emphasis on the development of new variations and substrates, and the acquisition of insights into relevant mechanistic aspects of this reaction. Its application to the synthesis of natural products, their analogs and bioactive compounds is also discussed.

Fields of Study & Subjects

Multicomponent Synthesis of Heterocycles Phosphorus compounds and reactions Synthesis and Characterization of Pyrroles

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
10
Pages
1965–1996
Publication date
1 January 2026
Language
EN