Rapid plasma membrane reorganisation and endocytosis in HER2 breast cancer cells incubated with trastuzumab decorated polymer nanoparticles

RSC Pharmaceutics 2026 Open access

Read full text
Authors: Carwyn Hughes, Saeed Tayeb, Duncan Muir, Anthony J. Hayes, Peter Watson, Arwyn Tomos Jones
DOI: 10.1039/d5pm00168d
Cited by: 1
References: 51

Abstract

PLGA nanoparticles decorated with trastuzumab inducing HER receptor clustering on the surface of breast cancer cells causing rapid plasma membrane reorganization captured by live resonant scanning confocal microscopy and SEM.

Fields of Study & Subjects

Nanoparticle-Based Drug Delivery Advanced Biosensing Techniques and Applications Lipid Membrane Structure and Behavior

Publication details

Journal / source
RSC Pharmaceutics
Publisher
Royal Society of Chemistry (RSC)
Volume
3
Issue
2
Pages
390–400
Publication date
1 January 2026
Language
EN