Lung physiologically based pharmacokinetic modelling to predict sublingual buprenorphine kinetics following oral inhalation

RSC Pharmaceutics 2026 Open access

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Authors: Tobechı Brendan Nnanna, Daniel Okwudili Nnamani, Elias Bestman Adikwu, Chisom Anthony Nnanna
DOI: 10.1039/d5pm00266d
Cited by: 0
References: 39

Abstract

An inhalation PBPK model was repurposed as a mechanistic surrogate for sublingual buprenorphine, capturing dose-dependent exposure via particle-size-driven deposition and mucosal dissolution while highlighting limits in terminal kinetics.

Fields of Study & Subjects

Inhalation and Respiratory Drug Delivery Advanced Drug Delivery Systems Pharmaceutical studies and practices

Publication details

Journal / source
RSC Pharmaceutics
Volume
3
Issue
2
Pages
585–603
Publication date
1 January 2026
Language
EN