Dual centrifugation – a novel perspective on lipid nanoparticle formulation development

RSC Pharmaceutics 2026 Open access

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Authors: Valentin Bender, L. Yolanda Fuchs, Monika Köll-Weber, Jan Lembeck, Laurine Kaul, Regine Süss, Ulrich Massing
DOI: 10.1039/d5pm00287g
Cited by: 1
References: 41

Abstract

Dual centrifugation enables a simplified and cost-effective preparation of RNA-loaded LNPs. Downscaled and DoE optimized to 1 mg batch sizes, the method offers a robust platform for LNP formulation development.

Fields of Study & Subjects

RNA Interference and Gene Delivery Advancements in Transdermal Drug Delivery Lipid Membrane Structure and Behavior

Publication details

Journal / source
RSC Pharmaceutics
Publisher
Royal Society of Chemistry (RSC)
Volume
3
Issue
3
Pages
711–725
Publication date
1 January 2026
Language
EN