nor -MC3 and nor -KC2: cationic ionizable lipids for the delivery of therapeutic nucleic acids

RSC Pharmaceutics 2026 Open access

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Authors: D.P. Arnold, N. D. Prasad Atmuri, Fariba Saadati, Ardalan A. Nabi, Daniel Z. Kurek, Anthony Tam, Taniya Adak, Dominik Witzigmann, Glenn M. Sammis, Pieter R. Cullis, Jayesh A. Kulkarni, Marco A. Ciufolini
DOI: 10.1039/d5pm00350d
Cited by: 0

Abstract

Analogues of MC3 and KC2 wherein C 17 lipophilic chains are present in lieu of C 18 ones exhibit favorable in vivo delivery relative to the originals and are easier and more economical to synthesize.

Fields of Study & Subjects

RNA Interference and Gene Delivery Nanoparticle-Based Drug Delivery Advancements in Transdermal Drug Delivery

Publication details

Journal / source
RSC Pharmaceutics
Volume
3
Issue
3
Pages
654–658
Publication date
1 January 2026
Language
EN