Overcoming stromal barriers in pancreatic cancer via size-engineered carrier-free nano-prodrugs

RSC Pharmaceutics 2026 Open access

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Authors: Mengheng Yang, Ryuju Suzuki, Yoshitaka Koseki, Shuto Kodera, Ken Saijo, Hisato Kawakami, Keita Tanita, Sanjay Kumar, Kouki Oka, Hitoshi Kasai
DOI: 10.1039/d5pm00364d
Cited by: 2
References: 35

Abstract

Carrier-free SNC4DC nanoparticles (30–400 nm) were fabricated by reprecipitation. Smaller particles showed faster SN-38 release and cellular uptake, and 30-nm nanoparticles achieved superior tumor inhibition in pancreatic cancer models.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Nanoparticle-Based Drug Delivery Graphene and Nanomaterials Applications

Publication details

Journal / source
RSC Pharmaceutics
Publisher
Royal Society of Chemistry (RSC)
Volume
3
Issue
3
Pages
694–700
Publication date
1 January 2026
Language
EN