Metal–atovaquone complexes with antiplasmodial activity: chemical reactivity and structure–activity relationships

Inorganic Chemistry Frontiers 2026

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Authors: Luana Vanessa Daniel, Chris Hebert J. Franco, Adrielle Sacramento de Morais, Arquı́medes Karam, Marcelo Cecconi Portes, Milena Barros Silva, Cristiane Barata-Silva, Lisia Maria Gobbo, Joël Mosnier, Isabelle Fonta, Ana Maria da Costa Ferreira, Bruno Pradines
+2 more Diogo Rodrigo de Magalhães Moreira, Maribel Navarro
DOI: 10.1039/d5qi02161h
Cited by: 2
References: 46

Abstract

Five new promising antimalarial metallodrugs (M (Ag, Zn, and Cu)–atovaquone (ATV)) were obtained. These demonstrate potent antimalarial activity, selectivity, and tunable action phenotypes.

Fields of Study & Subjects

Metal complexes synthesis and properties Magnetism in coordination complexes Multicomponent Synthesis of Heterocycles

Publication details

Journal / source
Inorganic Chemistry Frontiers
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
7
Pages
2961–2975
Publication date
1 January 2026
Language
EN