Pd( ii )-catalyzed aerobic dual C–N bond formation: oxygen-dependent divergence between dihydroquinazolinone and aza-Michael pathways, an experimental and computational study

Organic Chemistry Frontiers 2026

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Authors: Narges Mohammadi, Farnaz Jafarpour, Leyla Mohammadkhani, Alireza Ariafard
DOI: 10.1039/d5qo01381j
Cited by: 0
References: 39

Abstract

A selective, eco-friendly aerobic Pd( ii )-catalyzed three-component reaction in water converts isatoic anhydrides, anilines, and acrylamides to dihydroquinazolin-4(1 H )-ones. Without O 2 , the pathway switches to an aza-Michael adduct.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Quinazolinone synthesis and applications Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Organic Chemistry Frontiers
Volume
13
Issue
8
Pages
2331–2340
Publication date
1 January 2026
Language
EN