Asymmetric Michael–Mannich cascade reaction of azomethine ylides with isatin-derived trifluoromethyl acrylates catalyzed by a Cu( i ) catalyst

Organic Chemistry Frontiers 2026

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Authors: Xiaoying Cao, Pingde Tao, Saisai Yu, Shengwen Yang, Shi-Wu Li
DOI: 10.1039/d5qo01423a
Cited by: 1
References: 68

Abstract

An efficient, reliable and atom-economic strategy employing azomethine ylides with isatin-derived trifluoromethyl acrylates has been developed to afford spirooxindole-pyrrolidine products featuring vicinal quaternary carbon centers.

Fields of Study & Subjects

Fluorine in Organic Chemistry Cyclopropane Reaction Mechanisms Asymmetric Synthesis and Catalysis

Publication details

Journal / source
Organic Chemistry Frontiers
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
6
Pages
1814–1821
Publication date
1 January 2026
Language
EN