Photocatalytic 3D skeletal editing of carboxylic acids via [4 + 1] cyclization for streamlined synthesis of unsaturated γ-lactams

Organic Chemistry Frontiers 2026

View at publisher
Authors: Jiahui Yu, Xiaohong Li, Liangbin Huang
DOI: 10.1039/d5qo01548k
Cited by: 0
References: 58

Abstract

Herein, we report a photocatalytic strategy for the three-dimensional skeletal editing of carboxylic acids via sequential deoxygenation. It converts structurally diverse carboxylic acids into biologically unsaturated γ-lactams.

Fields of Study & Subjects

Radical Photochemical Reactions Chemical Synthesis and Analysis Organoboron and organosilicon chemistry

Publication details

Journal / source
Organic Chemistry Frontiers
Volume
13
Issue
5
Pages
1681–1687
Publication date
1 January 2026
Language
EN