An iodonium based cross-linking tool for tyrosine conjugation

Organic Chemistry Frontiers 2026

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Authors: Rihárd Sisa, János Tivadar Csenki, Flavián Domány, Dóra Ágocsi-Kiss, Levente Endre Dókus, Gábor Mező, Péter Pál Fehér, András Stirling, Anna Júlia Kiss-Szemán, Zoltán Novák
DOI: 10.1039/d5qo01572c
Cited by: 1
References: 72

Abstract

Selective fluoroalkenylation of tyrosine enables peptide cross-linking using a fluoroalkyl-aryl iodonium salt derived from HFO1234yf gas, forming unique 1,2-diaryloxyethene linkers. The mechanism was investigated and supported by calculations.

Fields of Study & Subjects

Fluorine in Organic Chemistry Oxidative Organic Chemistry Reactions Chemical Synthesis and Analysis

Publication details

Journal / source
Organic Chemistry Frontiers
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
7
Pages
2056–2064
Publication date
1 January 2026
Language
EN