Scandium-catalyzed asymmetric addition of allenylsilanes to β,γ-unsaturated α-ketoesters: enantioselective synthesis of tertiary homopropargylic allylic alcohols

Organic Chemistry Frontiers 2026

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Authors: Linxuan Wang, Xiangqing Jia, Chen‐Ho Tung, Zhenghu Xu
DOI: 10.1039/d5qo01584g
Cited by: 0
References: 60

Abstract

A scandium catalyzed regio- and enantioselective 1,2-homopropargylic addition of β,γ-unsaturated α-ketoesters was demonstrated, affording enantioenriched tertiary homopropargylic allylic alcohols in good yields with excellent enantioselectivities.

Fields of Study & Subjects

Catalytic Alkyne Reactions Asymmetric Synthesis and Catalysis Cyclopropane Reaction Mechanisms

Publication details

Journal / source
Organic Chemistry Frontiers
Volume
13
Issue
5
Pages
1531–1535
Publication date
1 January 2026
Language
EN