Diastereoselective synthesis of dioxaadamantane skeletons from coumarin-fused bridged ketones via a triple Grignard addition and hydroalkoxylation sequence

Organic Chemistry Frontiers 2026

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Authors: Haoran Yang, Jiawei Liu, Changmeng Yang, Dunru Zhu, Ruwei Shen
DOI: 10.1039/d5qo01594d
Cited by: 0
References: 47

Abstract

A sequential protocol involving triple allylic Grignard addition to coumarin-fused bridged ketones, followed by C–O bond-forming cyclization, is developed to access chromane-annulated dioxaadamantane skeletons with excellent diastereoselectivity.

Fields of Study & Subjects

Asymmetric Synthesis and Catalysis Organic Chemistry Synthesis Methods Advanced Synthetic Organic Chemistry

Publication details

Journal / source
Organic Chemistry Frontiers
Volume
13
Issue
8
Pages
2360–2366
Publication date
1 January 2026
Language
EN