Polysubstituted bicyclo-[2.1.1]-hexanes as benzene isosteres for medicinal chemistry

Organic Chemistry Frontiers 2026

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Authors: Eugenio Roà, Quentin Lefebvre
DOI: 10.1039/d5qo01662b
Cited by: 5
References: 120

Abstract

This comprehensive review describes the methodologies reported between 2020 and early 2025 for the synthesis of (hetero)bicyclo[2.1.1]hexane derivatives, organised by mechanisms and the exit vectors achieved.

Fields of Study & Subjects

Radical Photochemical Reactions Cyclopropane Reaction Mechanisms Oxidative Organic Chemistry Reactions

Publication details

Journal / source
Organic Chemistry Frontiers
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
8
Pages
2493–2598
Publication date
1 January 2026
Language
EN