Substrate-controlled mechanistic switch between protodemetalation and oxidative addition in Rh-catalyzed carbometalation: a DFT study

Organic Chemistry Frontiers 2026

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Authors: Chunhui Shan, Hong CHEN, Xiang Zhang, Xiaoling Luo
DOI: 10.1039/d5qo01672j
Cited by: 0
References: 36

Abstract

This DFT study reveals substrate-dependent mechanisms in Rh( i )-catalyzed carbometalation: dihydropyridines undergo insertion/protodemetalation, while dihydroquinolines favor oxidative addition, dictating enantioselectivity at different steps.

Fields of Study & Subjects

Organometallic Complex Synthesis and Catalysis Cyclopropane Reaction Mechanisms Asymmetric Synthesis and Catalysis

Publication details

Journal / source
Organic Chemistry Frontiers
Volume
13
Issue
5
Pages
1657–1666
Publication date
1 January 2026
Language
EN