Palladium-catalyzed Z -selective alkynylation of gem -difluoro alkenes via carbon–fluorine bond activation: mechanistic insights into oxygen-directed regiocontrol

Organic Chemistry Frontiers 2026

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Authors: Xin Liu, Min Liang, Jingyi Guo, Jin Yang, Jingyu Zhang, Yingsheng Zhao
DOI: 10.1039/d5qo01674f
Cited by: 1
References: 40

Abstract

Pd-catalyzed fluoroamino acid C–C coupling achieves Z -alkene synthesis via O-Pd stereocontrol. Validated mechanistically, pioneers amino acids as catalytic directors for fluorinated dehydroalkynyl derivatives.

Fields of Study & Subjects

Fluorine in Organic Chemistry Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Organic Chemistry Frontiers
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
7
Pages
2040–2047
Publication date
1 January 2026
Language
EN