Divergent oxidative annulation of primary aliphatic amines to access semi-saturated fused pyrimidines or quinazolines

Organic Chemistry Frontiers 2026

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Authors: Kang Liu, J. Li, Fanqian Li, Xinyi Tang, Xue Peng, Yao‐Fu Zeng, Xinping Liu, Guo-Jun Deng, Zhen Wang, Jinjin Chen
DOI: 10.1039/d5qo01676b
Cited by: 2
References: 63

Abstract

A novel multicomponent reaction enables the divergent synthesis of semi-saturated fused pyrimidines and quinazolines from cycloalkylamines, aldehydes and NH 4 I via oxidative annulation involving C(sp 3 )–H functionalization of primary aliphatic amines.

Fields of Study & Subjects

Quinazolinone synthesis and applications Catalytic C–H Functionalization Methods Multicomponent Synthesis of Heterocycles

Publication details

Journal / source
Organic Chemistry Frontiers
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
5
Pages
1636–1642
Publication date
1 January 2026
Language
EN