One-pot dearomatizative telescoped addition of C -nucleophiles to fluorinated 1,2,4-oxadiazoles followed by regioselective N -functionalization

Organic Chemistry Frontiers 2026 Open access

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Authors: Davide Castiglione, Sara Amata, Federica Lauria, Andrea Maranzana, Salvatore Baldino, Alexander Roller, Laura Castoldi, Antonio Palumbo Piccionello, Vittorio Pace, Eisuke I. Comas Iwasita
DOI: 10.1039/d5qo01707f
Cited by: 0
References: 71

Abstract

The constitutive low aromaticity of easily accessible 5-trifluoromethyl-1,2,4-oxadiazoles is explored to enable editing modification to the corresponding unprecedented gem -disubstituted 1,2,4-oxadiazolines.

Fields of Study & Subjects

Structural and Chemical Analysis of Organic and Inorganic Compounds Fluorine in Organic Chemistry Carbon dioxide utilization in catalysis

Publication details

Journal / source
Organic Chemistry Frontiers
Volume
13
Issue
8
Pages
2401–2409
Publication date
1 January 2026
Language
EN