Design, synthesis, molecular docking, and antimicrobial evaluation of hybrid peptides incorporating unnatural amino acids with enhanced hydrophobic sidechains

RSC Advances 2026 Open access

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Authors: Subhash Rao Marata, Tushar Janardan Pawar, José Luís Olivares-Romero, Harun Patel, Iqrar Ahmad, Enrique Delgado-Alvarado, Ghazala Muteeb, Nagendra Govindappa, Meghali Devi, Siddhant V. Kokate, Lakshmi Basavegowda
DOI: 10.1039/d5ra05259a
Cited by: 2
References: 56

Abstract

. These results establish unnatural amino acid-based peptides as promising candidates in addressing MDR infections, warranting further studies for clinical application.

Fields of Study & Subjects

Antimicrobial Peptides and Activities Chemical Synthesis and Analysis Antimicrobial agents and applications

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
12
Pages
11090–11099
Publication date
1 January 2026
Language
EN