Advancing total synthesis through the Stille cross-coupling: recent innovations and case studies
Abstract
's foundational work, this method has evolved through innovations in catalysis, ligand design, and eco-friendly protocols to address challenges like tin toxicity. This review highlights its application in constructing complex molecules and emphasizes advancements in bond-forming strategies. The reaction's versatility in both intermolecular and intramolecular contexts, coupled with its functional group tolerance, underscores its enduring relevance in modern organic synthesis of naural products.
Fields of Study & Subjects
Catalytic Cross-Coupling Reactions
Catalytic Alkyne Reactions
Synthetic Organic Chemistry Methods
Publication details
- Journal / source
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 16
- Issue
- 3
- Pages
- 2475–2503
- Publication date
- 1 January 2026
- Language
- EN