Novel cinnamic acid-based N -benzyl pyridinium analogs: potent dual cholinesterase inhibitors with neuroprotective properties for Alzheimer's disease

RSC Advances 2026 Open access

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Authors: Maryam Esmkhani, Mohammad Mahdavi, Shahrzad Javanshir, Aida Iraji
DOI: 10.1039/d5ra06941f
Cited by: 2
References: 23

Abstract

= 0.49 µM). Furthermore, molecular docking and molecular dynamics simulations identified stable binding interactions in the active sites of AChE and BChE. All these findings support the potential of these compounds as effective multi-target-directed ligands (MTDLs) for AD, displaying coordinated inhibition of cholinesterase, neuroprotection, and low toxicity.

Fields of Study & Subjects

Cholinesterase and Neurodegenerative Diseases Enzyme function and inhibition Alzheimer's disease research and treatments

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
10
Pages
9293–9306
Publication date
1 January 2026
Language
EN