Piperidine-catalyzed synthesis of ( E )-2-cyanoacrylamides: crystallographic, antiproliferative, and docking studies

RSC Advances 2026 Open access

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Authors: Camilo Serrano-Sterling, Isabel Iriepa, Mario A. Macías, Juan-Carlos Castillo, Diana Becerra
DOI: 10.1039/d5ra07121f
Cited by: 4
References: 61

Abstract

ratios equal to or greater than 100 indicated selective growth inhibition rather than nonspecific cytotoxicity. Compound 3n exhibited a slightly higher cytotoxic response compared with its structural analogues. To rationalize this behavior, toxicity profiling revealed a coordinated activation of Nrf2-mediated oxidative stress, p53-dependent DNA damage response, and androgen receptor (AR-LBD) signaling pathways. Molecular docking studies further demonstrated favorable binding interactions of compounds 3f, 3n, and 3o within the tyrosine kinase domain of the epidermal growth factor receptor (EGFR), with predicted affinities surpassing that of Erlotinib.

Fields of Study & Subjects

Multicomponent Synthesis of Heterocycles Catalytic Cross-Coupling Reactions Phosphorus compounds and reactions

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
1
Pages
819–835
Publication date
1 January 2026
Language
EN