Design, synthesis, and biological evaluation of novel chalcone derivatives: integrating molecular docking with in vivo anti-inflammatory and antinociceptive studies

RSC Advances 2026 Open access

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Authors: Abida Shamim, Humaira Nadeem, Syed Muzzammil Masaud, Tajamul Hussain, Kashif Bashir, Salman Alrokayan, Ihsan-ul Haq, Muhamamd Latif, Muhammad Imran, Nadeem Irshad
DOI: 10.1039/d5ra07230a
Cited by: 2
References: 65

Abstract

analyses underscores the potential of these chalcone analogues as selective COX-2 inhibitors. These findings highlight the value of structure-guided design in developing dual-function chalcones with anti-inflammatory and antinociceptive activity, warranting further optimization and preclinical evaluation.

Fields of Study & Subjects

Synthesis and biological activity Cholinesterase and Neurodegenerative Diseases Melanoma and MAPK Pathways

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
4
Pages
2996–3020
Publication date
1 January 2026
Language
EN