Graphene field-effect transistor based multiplexed sensing platform for simultaneous detection of multiple Alzheimer's disease biomarkers

RSC Advances 2026 Open access

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Authors: Biyu Guo, Jiangyang Wang, Feige Lou, Baowei Yuan, Zhibo Chen, Chengjie Tang, Weiao Chen, Fangxuan Yi, Jingjing Jiang, Guangxi Hu, Chunxiao Cong, Ye Lu
DOI: 10.1039/d5ra07384g
Cited by: 1
References: 29

Abstract

), and this further enables simultaneous detection of multiple targets (multi-targets) in complex biological samples. The optimized aptamer/probe functionalization also enhances the specificity, sensitivity, and accuracy of the sensor. The technology was demonstrated with Alzheimer's disease (AD) biomarkers as a case study. Two distinctive biomarkers, hsa-miR-125b and Aβ42, are detected simultaneously with distinguishable signatures, and the lowest tested concentration is 1 fM. The cross-check experiments also show the effectiveness of the multi-target detection capability. This concise platform paves the way for accurate detection of early-stage diseases when the simultaneous identification of multiple biomarkers is required.

Fields of Study & Subjects

Nanowire Synthesis and Applications Graphene research and applications Advanced biosensing and bioanalysis techniques

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
26
Pages
23937–23944
Publication date
1 January 2026
Language
EN