Design, synthesis, in silico studies, and antiproliferative activity of a novel series of thiazole/1,2,3-triazole hybrids as apoptosis inducers and multi-kinase inhibitors endowed with anti-breast cancer activity

RSC Advances 2026 Open access

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Authors: Fatma A. M. Mohamed, Saleha Y M Alakilli, Hassan Hamdan Alhassan, Sara Osman Yousif, Eid Alatwi, Hesham A. M. Gomaa, Heba Abu Alrub, Bandar A. Alyami, Ahmed H. Abdelhafez, Stefan Bräse, Bahaa G. M. Youssif
DOI: 10.1039/d5ra07556d
Cited by: 4
References: 60

Abstract

docking studies against EGFR, HER-2, and VEGFR-2 revealed the importance of the phenyl 1,2,3-triazole moiety and the chalcone side chain in anticancer activity. The most potent compounds demonstrated drug-like properties and could serve as prototypes for future optimization. Compounds 10e and 10k may serve as examples of multi-targeting anticancer agents that function by blocking the EGFR, HER-2, and VEGFR-2 kinases.

Fields of Study & Subjects

Click Chemistry and Applications Synthesis and biological activity Synthesis and Reactivity of Heterocycles

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
4
Pages
3349–3367
Publication date
1 January 2026
Language
EN