Multi-responsive upconversion/organic porous silicon nanocomposite for controlled drug release via NIR irradiation and tumor microenvironment stimuli

RSC Advances 2026 Open access

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Authors: Xiaotao Wang, Zhihao Bi, Yonggui Liao, Chak-Yin Tang, Xuefeng Li, Wing‐Cheung Law
DOI: 10.1039/d5ra07668d
Cited by: 2
References: 51

Abstract

cellular assays showed that synergistic stimuli-NIR irradiation combined with an acidic, GSH-rich microenvironment-trigger controllable DOX release, enabling efficient tumor cell ablation. This work demonstrates a versatile, multi-responsive delivery platform combining UCNP-based photoreactivity, GSH-triggered degradation, and photoactive surface gating to achieve targeted, low-toxicity, on-demand chemotherapy.

Fields of Study & Subjects

Silicon Nanostructures and Photoluminescence Mesoporous Materials and Catalysis Silicone and Siloxane Chemistry

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
6
Pages
5168–5178
Publication date
1 January 2026
Language
EN