Positive modulators of N -methyl- d -aspartate receptor: structure–activity relationship study on steroidal C-17 and C-20 oxime ethers

RSC Advances 2026 Open access

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Authors: Santosh Kumar Adla, Barbora Hrčka Krausová, Bohdan Kysilov, Karel Kudláček, Radko Souček, Milos Budesinsky, Jan Voldřich, Ladislav Vyklický, Eva Kudová
DOI: 10.1039/d5ra07716h
Cited by: 1
References: 56

Abstract

ADME profiles, including high metabolic stability and, for 12, excellent thermodynamic solubility. These results validate C-20 oxime ether modification of the pregnenolone scaffold as an effective strategy for generating potent NMDAR PAMs with potentially superior efficacy and drug-like properties compared to endogenous modulators.

Fields of Study & Subjects

Neuroscience and Neuropharmacology Research Estrogen and related hormone effects Menopause: Health Impacts and Treatments

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
12
Pages
10769–10784
Publication date
1 January 2026
Language
EN