Evaluating the biological characteristics of targeted ZIF-8-encapsulated individual and combined drug systems for enhanced in vivo toxicity mitigation using folic acid ligands

RSC Advances 2026 Open access

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Authors: Noor Sameer Sadeq, Mas Jaffri Masarudin, Mohd Basyaruddin Abdul Rahman, Suet Lin Chia, Syahida Ahmad, HASLINA AHMAD
DOI: 10.1039/d5ra07756g
Cited by: 4
References: 76

Abstract

) with significant improved survivability (90%) until 120 h of incubation. Results showed that RuPIP-Olap@ZIF8-FA did not cause significant malformations, even at elevated concentrations, and did not present aggregation issues toward healthy embryos. These findings establish RuPIP-Olap@ZIF-8-FA as a promising dual-drug nanocarrier capable of targeted delivery, pH-triggered release, and distinct therapeutic pathways. Its high loading efficiency, simplicity, and improved safety profile highlight its strong potential for advancement toward clinical translation.

Fields of Study & Subjects

Metal-Organic Frameworks: Synthesis and Applications Nanoparticle-Based Drug Delivery Graphene and Nanomaterials Applications

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
2
Pages
1912–1931
Publication date
1 January 2026
Language
EN