Dual-targeting sulfamethoxazole derivatives overcome multidrug resistance in ESKAPE pathogens by inhibiting quorum sensing and efflux pumps

RSC Advances 2026 Open access

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Authors: Benedicta Yayra Adzah, Prince Danan Biniyam, Victoria Ohene‐Adu, Michael Osei, Kwabena Adu-Adjei, Victoria K. Elmes, Iain Goodall, Vuvor Faustina, Yvonne Dogbeda Agboyibor, Patrick Gyan, Paul Quansah, Cyril Makafui Amengor
+7 more Cyril Makafui Amengor, Joshua Ofori Boateng, En Zhang, Maxwell Ampomah-Wireko, Ernest Oyeh, Cedric Dzidzor Kodjo Amengor, Cedric Dzidzor Kodjo Amengor
DOI: 10.1039/d5ra08024j
Cited by: 1
References: 69

Abstract

An integrated computational and experimental approach validated five (5) sulphamethoxazole derivatives targeting dihydropteroate synthase (DHPS) protein as dual inhibitors of quorum sensing (LasR) and efflux pumps (AcrB) with SMX033 as the best hit.

Fields of Study & Subjects

Pneumocystis jirovecii pneumonia detection and treatment Antibiotic Resistance in Bacteria Legionella and Acanthamoeba research

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
10
Pages
8921–8944
Publication date
1 January 2026
Language
EN