Vanillin-tethered quinazolin-2,4-dione analogues through five- and/or six-membered nitrogen-containing heterocycles as antibacterial agents: synthesis, biological evaluation and molecular docking study
Abstract
attached to pyrazole and/or isoxazole moieties, respectively. To evaluate the structural confirmation and chemical reactivity behavior of the quinazolin-2,4-dione skeleton, semiempirical studies were achieved. Overall, the findings underscore the potential of vanillin linked to quinazolin-2,4-dione skeletons through five- and/or six-membered nitrogen-containing heterocycles, particularly 2, 5 and 11, as promising candidates for development of potent antibacterial inhibitors.
Fields of Study & Subjects
Quinazolinone synthesis and applications
Synthesis and biological activity
Synthesis and Biological Evaluation
Publication details
- Journal / source
- RSC Advances
- Volume
- 16
- Issue
- 7
- Pages
- 5726–5742
- Publication date
- 1 January 2026
- Language
- EN