Design, synthesis, in vitro , and in silico studies on promising α-glucosidase inhibitors based on a quinazolinone–thiophene scaffold

RSC Advances 2026 Open access

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Authors: Parsa Baghershahi, Navid Dastyafteh, Mohammad Halimi, Maryam Mohammadi-Khanaposhtani, Seyedeh Niloufar Ghafouri, Milad Noori, Fahimeh Ghasemi, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Mohammadreza Torabi, Majid Alikhani, Bagher Larijani
+2 more Shahrzad Javanshir, Mohammad Mahdavi
DOI: 10.1039/d5ra08206d
Cited by: 2
References: 35

Abstract

for druglikeness, pharmacokinetics, and toxicity. These evaluations revealed that, in terms of druglikeness and pharmacokinetics, the new compounds were similar to acarbose, while they showed better toxicity profiles. Furthermore, the most potent compounds exhibited low cytotoxicity against normal NIH-3T3 cells.

Fields of Study & Subjects

Quinazolinone synthesis and applications Carbohydrate Chemistry and Synthesis Synthesis of Tetrazole Derivatives

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
7
Pages
6190–6209
Publication date
1 January 2026
Language
EN