Chromatography's evolution, unlocking affinity's new solution: potential-controlled affinity membrane chromatography

RSC Advances 2026 Open access

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Authors: Tobias Steegmüller, Maeliss Nzokam, Christian Sieg, David Golonka, Nina Fridley, Sebastian P. Schwaminger, Sonja Berensmeier
DOI: 10.1039/d5ra08238b
Cited by: 3
References: 25

Abstract

Dynamic Light Scattering (DLS), Size-Exclusion Chromatography (SEC) with Multi-Angle Light Scattering (SEC-MALS), and Surface-Plasmon-Resonance (SPR), demonstrated superior retention of antibody integrity. Our potential-controlled affinity membrane chromatography (PCAMC) offers a revolutionary alternative to traditional techniques, boosting efficiency and sustainability while overcoming the limitations of conventional affinity methods. This study sets the stage for a cost-effective and eco-friendly future in antibody therapeutics.

Fields of Study & Subjects

Protein purification and stability Monoclonal and Polyclonal Antibodies Research Viral Infectious Diseases and Gene Expression in Insects

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
7
Pages
6061–6068
Publication date
1 January 2026
Language
EN