Biocatalyzed aza-michael addition via continuous flow technology: a game-changer for the facile synthesis of N- alkylated pyrazole derivatives

RSC Advances 2026 Open access

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Authors: Li‐Hua Du, Bing-Lin Yan, Miaomiao Xue, Lin Wang, Luo Xi-ping
DOI: 10.1039/d5ra08312e
Cited by: 0
References: 45

Abstract

An efficient continuous-flow biocatalytic synthesis of N -alkylated pyrazoles was established, with 25 derivatives prepared to verify applicability and supply pharmaceutical parameters.

Fields of Study & Subjects

Enzyme Catalysis and Immobilization Innovative Microfluidic and Catalytic Techniques Innovation Asymmetric Synthesis and Catalysis

Publication details

Journal / source
RSC Advances
Volume
16
Issue
3
Pages
2850–2857
Publication date
1 January 2026
Language
EN