Study on the synthesis and biological activity of kojic acid–piperazine derivatives
Abstract
= 0.93 µM). Fluorescence quenching experiments confirmed a dynamic quenching mode. Furthermore, molecular docking and FT-IR studies revealed that compound 3o binds to the C[double bond, length as m-dash]O and N-H bonds of tyrosinase. Specifically, its kojic acid fragment interacts with the copper ion active site and adjacent amino acid residues, while the piperazine ring fragment forms π-π interactions with other residues. Additionally, compound 3o demonstrated notable anti-browning and antioxidant activities, exhibited low cytotoxicity. In conclusion, these findings highlight compound 3o as a highly promising candidate, providing a valuable molecular framework for developing novel, efficient, and safe tyrosinase inhibitors with potent antioxidant and anti-browning capabilities.
Fields of Study & Subjects
melanin and skin pigmentation
Glycosylation and Glycoproteins Research
Mast cells and histamine
Publication details
- Journal / source
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 16
- Issue
- 2
- Pages
- 1344–1356
- Publication date
- 1 January 2026
- Language
- EN