To contact or not: an investigation into the polymeric surface interactions with human insulin and their therapeutic implications
Abstract
to map pH alterations within insulin agglomerates. Larger agglomerates, with higher lifetime variations, were noticed for the amine-terminated particles, especially at longer timepoints, whereas such fluctuations were relatively subtle in the acid-terminated ones. Regions with lifetime variation spread beyond the adsorbed insulin layer on particles and merged with the peripheral zones of lower lifetimes inside the agglomerates. The results suggest that polymeric surfaces alter insulin's biochemical properties, with probable implications of reduced bioactivity, poor glycemic control, and (potential) additional side effects.
Fields of Study & Subjects
Polymer Surface Interaction Studies
Diabetes Management and Research
Nanoparticle-Based Drug Delivery
Publication details
- Journal / source
- RSC Advances
- Volume
- 16
- Issue
- 10
- Pages
- 8584–8592
- Publication date
- 1 January 2026
- Language
- EN