Development of substituted 2-(4-(sulfonyl)piperazin-1-yl)quinazoline molecular hybrids as a new class of antimalarials

RSC Advances 2026 Open access

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Authors: Hari Madhav, Ashutosh Panda, Dipanwita Datta, Kashfa Shaheen, Abdur Rahman, Azhar Tariq Khan, Souvik Bhattacharjee, Dhiraj Kumar, Pawan Malhotra, Nasimul Hoda
DOI: 10.1039/d5ra08515b
Cited by: 0
References: 69

Abstract

, respectively. The predicted ADME properties of the compounds fall within the Schrödinger range, which encompasses 95% of all known medications. The study thus emphasised the significance of the molecular hybridisation approach and highlighted compounds 19 and 27 as potent hit molecules that could be further optimised for the development of new antimalarials.

Fields of Study & Subjects

Quinazolinone synthesis and applications Malaria Research and Control Synthesis and biological activity

Publication details

Journal / source
RSC Advances
Volume
16
Issue
1
Pages
617–641
Publication date
1 January 2026
Language
EN