Enhanced controlled drug delivery of berberine-loaded gelatin nanoparticles: characterization and in vitro assessment

RSC Advances 2026 Open access

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Authors: Hoda A. Sharaf, Mona Saied, Doaa A. Ghareeb, Sherif Kandil, Ahmed Abd El-Fattah
DOI: 10.1039/d5ra08567e
Cited by: 7
References: 41

Abstract

release studies demonstrated a biphasic and sustained release profile extending over three weeks. The biological evaluation of BBR-GNPs indicated notable antimicrobial, antioxidant, and biocompatibility characteristics. Moreover, MTT assay results showed high cell viability of human skin fibroblasts in a dose-dependent manner, confirming the safety of the developed formulation. Overall, this work presents BBR-GNPs as a promising nanoplatform for controlled drug delivery, offering enhanced solubility, prolonged release, and improved bioavailability of BBR, thereby extending its potential therapeutic applications.

Fields of Study & Subjects

Berberine and alkaloids research Nanoparticle-Based Drug Delivery Andrographolide Research and Applications

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
7
Pages
6119–6131
Publication date
1 January 2026
Language
EN