Regulation of infant gut microbiota and metabolic pathways by human milk oligosaccharides: a multi-omics investigation

RSC Advances 2026 Open access

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Authors: Lingling Luo, Baoyu Yang, Junying Zhao, Xianping Li, Weicang Qiao, Minghui Zhang, Li Tian, Lijun Chen
DOI: 10.1039/d5ra08644b
Cited by: 7
References: 74

Abstract

and acetate production, were detected. Overall, these findings indicate that the gut flora-metabolite interplay is central to HMO function, and different HMOs variably regulate the gut microbiota composition and metabolic pathways. This study provides a theoretical basis for optimizing HMOs' fortification strategies in infant formulas.

Fields of Study & Subjects

Infant Nutrition and Health Gut microbiota and health Glycosylation and Glycoproteins Research

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
6
Pages
5641–5651
Publication date
1 January 2026
Language
EN