Comprehensively investigating pharmacokinetics and metabolic fate of andrographolide in rats by liquid chromatography/mass spectrometry-based approach

RSC Advances 2026 Open access

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Authors: Xuelin Sun, Yatong Zhang, Zhanpeng Shang, Lin Dou, T Y Wang, Jiantao Qiu, Shuang Chen
DOI: 10.1039/d5ra08654j
Cited by: 2
References: 27

Abstract

In vivo disposition of Andrographolide was studied in rats. It showed high elimination and moderate bioavailability. 34/39 metabolites were sulfated, making sulfation its main pathway. A novel MS/MS workflow identified 4 sulfation sites.

Fields of Study & Subjects

Andrographolide Research and Applications Traditional Chinese Medicine Analysis Magnolia and Illicium research

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
13
Pages
11348–11360
Publication date
1 January 2026
Language
EN